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SR9011

SR9011

SR9011 Quick details : Cas No.: 1379686-29-9 Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide Formula: C23H31ClN4O3S Molucelar weight: 479.03524 SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal...

Product Details


SR9011 Quick details :


Cas No.: 1379686-29-9
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols.
Usage levels of 5% to 10% by weight are recommended.



SR9011 Description


SR9011 is a potent and specific synthetic REV-ERB. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-?? and REV-ERB-?? play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.



How to Use SR9011


In vitro: SR9011 was used at 5-10 M concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models. 

Up to now, no side effects have been observed with SR9011, so it may be seen as an extremely safe compound.  Moreover, just like in the case of other SARMS, SR9009 is not liver toxic, but there is a need for liver supporting supplements when using it.  N2Guard at 3-5 capsules per day will be sufficient liver and kidney support.


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