Contact US
Address: South Time 16 building 1 Unit Room 1102 Nansha, Guangzhou, Guangdong
TEL: 86-20-28125195
FAX : 86-20-28125195
Oxytocin Peptides Release Neuropeptide Hormone Stimulates Acetate Salt Hydrate

Oxytocin Peptides Release Neuropeptide Hormone Stimulates Acetate Salt Hydrate

Oxytocin Quick Details : Synonyms: Pitocin,Oxytocin acetate salt hydrate,Ocytocinum,Alpha-Hypophamine Unit size: 2 mg/vial CAS NO.: 50-56-6 Sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 Purity: 98.2% Physical State: Lyophilized Powder Solubility: Soluble in water or 1% acetic acid Storage:...

Product Details

Oxytocin Peptides Release Neuropeptide Hormone Stimulates Acetate Salt Hydrate

Oxytocin Quick Details : 


Synonyms: Pitocin,Oxytocin acetate salt hydrate,Ocytocinum,Alpha-Hypophamine
Unit size: 2 mg/vial
CAS NO.: 50-56-6
Sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Purity: 98.2%
Physical State: Lyophilized Powder
Solubility: Soluble in water or 1% acetic acid
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18℃. Upon reconstitution of the peptide it should be stored at 4℃ between 2-21 days and for future use below -18℃
Usage : a peptide hormone and neuropeptide , used as a medication to facilitate childbirth
It plays a role in social bonding, sexual reproduction in both sexes, and during and after childbirth.


Oxytocin Description : 


Oxytocin is a peptide hormone and neuropeptide. Oxytocin is also used as a medication to facilitate childbirth.Oxytocin is normally produced by the paraventricular nucleus of the hypothalamus and released by the posterior pituitary.  


Oxytocin is normally made by the particular paraventricular nucleus on the hypothalamus gland and also introduced by way of the rear pituitary. It makes a contribution to community relationship, lovemaking replica in genders, and through after labor. Oxytocin is certainly produced in to the bloodstream as the hormonal agent in reply to a stretching program in the cervix along with uterus in the course of toil together with stimulation within the nipples from nursing a baby.It will help together with childbirth, bonding using the infant, together with whole milk output.] Oxytocin is discovered by just Henry Dale with 1906.It has the molecular construction was discovered within 1952.
 Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders, and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD). 


 Oxytocin (OXT) is actually a potent natriuretic hormonal encoded by way of the gene mapped for you to human being chromosome 20p13. Its produced along with its bag protein neurophysin We in the non-active forerunner prepro-OXT. OXT gene consists of three exons and two introns, where primary exon codes designed for bodily chemical OXT while alternative exon requirements with regard to neurophysin I actually.


Oxytocin is a mammalian hormones, can in the brain under thalamic "paraventricular nuclear" and "nuclear neurons the natural secretion. For women, it can cause uterine contractions during labor, and stimulate the production of milk (rather than the secretion). In addition, it can reduce the body's adrenal glands and other stress hormone levels, in order to reduce blood pressure. It is not a woman's patent, men and women can secrete.


The actual oxytocin peptide is certainly created just as one non-active forerunner protein on the OXT gene.This particular forerunners necessary protein also includes the oxytocin carrier necessary protein neurophysin Any sedentary forerunner proteins are slowly hydrolyzed into more compact broken phrases (one of which is neurophysin My partner and i) using a group of digestive support enzymes. The final hydrolysis which will secretes any effective oxytocin nonapeptide is catalyzed by means of peptidylglycine alpha-amidating monooxygenase (PAM). 


The game with the PAM compound method is depending on ascorbic acid (ascorbate), the needed nutrient cofactor. By accident, sea ascorbate by itself was discovered that will stimulate the production of oxytocin out of ovarian cellular material more than a array of values within a dose-dependent fashion. Most of the same areas (electronic.gary the gadget guy. ovaries, testicles, face, adrenals, placenta, thymus, pancreas) in which PAM (as well as oxytocin automatically) is available can also known to maintain bigger amounts with ascorbic acid Oxytocin is proven to be digested by the oxytocinase, leucylstinyl aminopeptidase . Other oxytocinases can also be known in order to occur.Amastatin, bestatin (ubenimex), leupeptin, plus puromycin have been found so that you can inhibit the actual enzymatic deterioration connected with oxytocin, even though additionally, they restrict the actual deterioration of additional proteins, like vasopressin, met-enkephalin, together with dynorphin

 

Oxytocin Application :


Oxytocin has been best known for its roles in female reproduction. It is released in large amounts during labor, and after stimulation of the nipples. It is a facilitator for childbirth and breastfeeding. However, recent studies have begun to investigate oxytocin's role in various behaviors, including orgasm, social recognition, bonding, and maternal behaviors. This small nine amino acid peptide is now believed to be involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterine contraction, milk ejection, maternal behavior, social bonding, stress and probably many more, which makes oxytocin and its receptor potential candidates as targets for drug therapy.


Oxytocin is a neuropeptide stated in a hypothalamus plus secreted via the pituitary gland.
Oxytocin is definitely introduced during sex, birth and also lactation to help reproductive : features.
That neuropeptide exerts various mental health results, impacting on cultural habits and feelings.
Oxytocin is actually approved for a variety of obstetric and gynecological purposes, such as to assist in childbirth.
Great amount "love hormone" are already affecting young couples from the to begin with six months time of a relationship. 

Oxytocin has a anti-anxiety (anxiolytic) result and may improve amorous accessory in addition to empathy. 


Research shows this oxytocin can have health benefits for individuals with autistic variety issues.
Oxytocin appears to be lead to shielding any intestinal tract coming from ruin, by using prospect of utilization in remedy for stressed out bowel diseases.


Oxytocin acetate salt hydrate use a skin moisturizer has been used during mobile phone expansion analysis and it is employed in trials to learn the issue for oxytocin from the prelimbic (PL) place within the inside prefrontal cortex (mPFC) regarding stress and anxiety. It really is utilized for a gun within receptor autoradiography to evaluate nonspecific cells joining within the periphery within the neonatal mouse button.


Injected oxytocin analogues are used for labor induction and to support labor in case of difficult parturition. It has largely replaced as the principal agent to increase uterine tone in acute postpartum hemorrhage. Oxytocin is also used in veterinary medicine to facilitate birth and to stimulate milk release. The tocolyticagent atosiban (Tractocile) acts as an antagonist of oxytocin receptors; this drug is registered in many countries to suppress premature labor between 24 and 33 weeks of gestation. It has fewer side effects than drugs previously used for this purpose (ritodrine).

 

 Oxytocin Specifications(COA)
   


 Oxytocin COA:
  

Name of P roduct:

Oxytocin Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

Batch No:

1704015

Analyzed on:

2017-4-20

Date of Manufacture:

2017-4-20

Quantity:

30g

CAS No.:

50-56-6

Expiry Date:

2019-4-19

TEST

SPECIFICATION

RESULTS

Characteristic

White or almost white powder.

White powder

Identification A. HPLC

Retention time conforms to that of the reference standard

Conforms

B. Amino acids

Asp: 0.90-1.10;Glu: 0.90-1.10 Pro: 0.90-1.10;Gly: 0.90-1.10 Leu: 0.90-1.10;Tyr: 0.7-1.05 Half-Cys: 1.4-2.1;Ile: 0.90-1.10

Conforms

pH

3.0-6.0

5.0

Related substances
(HPLC)
      
      
      
      

Impurity A¡Ü1.5%
Impurity B¡Ü1.5%
Impurity C¡Ü1.5%
Other single impurity¡Ü0.5%
Total impurities¡Ü5.0%

0.15%
0.20%
Not Detected
0.13%
0.7%

Acetic acid (HPLC)

6.0%-10.0%

7.1%

Water(KF)

NMT 5.0%

1.4%

Bacterial endotoxins

Less than 300 IU/mg

Conforms

AcN(GC)

Not more than 0.041%

Conforms

MeOH(GC)

Not more than 0.3%

Conforms

Triethylamine(GC)

Not more than 0.032%

Conforms

Assay Calculated with reference to anhydrous, aceticacid free substance

93.0%-102.0%

98.8%

On powder

NLT 80.0 %

90.4%

 

NLT 480 IU/mg

542IU/mg

 

Related Products