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Phenacetin 62-44-2 White Raw Analgesic Powder

Phenacetin 62-44-2 White Raw Analgesic Powder

Phenacetin Property: Name: Phenacetine Storage temp: 2-8°C Color: white powder Water Solubility: 0.076 g/100 mL Sensitive: Hygroscopic Merck: 14,7204 BRN: 1869238 Stability: Stable. Incompatible with strong oxidizing agents, strong acids. Application: Its analgesic effects are due to its actions...

Product Details

Phenacetin Property:

Name: Phenacetine

Storage temp: 2-8°C

Color: white powder

Water Solubility: 0.076 g/100 mL

Sensitive: Hygroscopic

Merck: 14,7204

BRN: 1869238

Stability: Stable. Incompatible with strong oxidizing agents, strong acids.


Application:


Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetis has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treatrheumatoid arthritis (subacute type) and intercostal neuralgia.


Function:


Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetins-Acetate not be converted into paracetamol, still showed
obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The
mild phenacetins-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid
coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.


COA:



Item
SpecificationsResults
DescriptionWhite or almost white crystalline powderConform

Identity
1,IR compliesConform
2,X-Ray compliesConform
3,HPLC compliesConform
Optical rotation-77.0-78.0
Loss on dryingNot more than 0.5%0.32%



Related substances
1,Cabergolin Imp A no more than0.15%0.05%
2,Allylamide no more than 0.10%0.03%
3,Allyl DHLA no more than 0.15%0.06%
4,Cabergoline oxide no more than 0.10%0.04%
5,Other impurities individually no more than 0.10%0.03%
6,Total no more than 0.50%0.21%
Assay(HPLC)98.0%~102.0%(recalculated on anhydrous basis)99.4%


Residual solvents
1,Dichloromethane no more than 100ppm15ppm
2,Acetone no more than 200ppm15ppm
3,Tert-butylmethylether no more than 200ppm11ppm
4,Xylene no more than 1500ppm135ppm
5,Heptane no more than 1000ppm20ppm
Residue on ignitionNo more than0.10%0.03%
Heavy metalsNo more than 20ppm1ppm
Particle size90% of particles no more than 80umConform
Bulk density0.20~0.35g/cm30.33g/cm3
ConclusionThe results conforms with EP6.0/USP30 standard.


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